Inhibition of norfloxacin absorption by dairy products

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Inhibition of norfloxacin absorption by dairy products.

Seven healthy subjects received, after an overnight fast, a single 200-mg oral dose of norfloxacin with water, whole milk, and unflavored yoghurt. Coadministration of milk or yoghurt reduced the extent of norfloxacin absorption and the mean peak concentration in plasma by approximately 50%. Taking of norfloxacin with these liquid dairy products should be avoided.

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1992

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.36.2.489